Functional MRI of Brain Activity at Rest in Health and Disease. Serge Rombouts Leiden University Medical Center With MR neuroimaging techniques, we can study brain structure, including structural connectivity, and brain function (and functional connectivity) using FMRI. These techniques are used to, for example, study their potential for diagnosing Alzheimer¹s disease in an early stage, to study changes in the brain with psychiatric diseases, and to study the effect of drugs on brain activation. More recently, there is an increasing interest in so called Œresting state FMRI connectivity¹. I will present some basics of these current neuroimaging methods, including FMRI, Œresting state¹, and show applications of neuroimaging studies including Alzheimer¹s disease and pharmacologic FMRI.